RICERCA SCIENTIFICA OMEOPATICA

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Messaggiodi Dr.Ascani il mer giu 01, 2016 1:34 pm

Improved clinical status in fibromyalgia patients treated with individualized homeopathic remedies versus placebo.

Abstract

OBJECTIVE:

To assess the efficacy of individualized classical homeopathy in the treatment of fibromyalgia.

METHODS:

This study was a double-blind, randomized, parallel-group, placebo-controlled trial of homeopathy. Community-recruited persons (N = 62) with physician-confirmed fibromyalgia (mean age 49 yr, s.d. 10 yr, 94% women) were treated in a homeopathic private practice setting. Participants were randomized to receive oral daily liquid LM (1/50,000) potencies with an individually chosen homeopathic remedy or an indistinguishable placebo. Homeopathic visits involved joint interviews and concurrence on remedy selection by two experienced homeopaths, at baseline, 2 months and 4 months (prior to a subsequent optional crossover phase of the study which is reported elsewhere). Tender point count and tender point pain on examination by a medical assessor uninvolved in providing care, self-rating scales on fibromyalgia-related quality of life, pain, mood and global health at baseline and 3 months, were the primary clinical outcome measures for this report.

RESULTS:

Fifty-three people completed the treatment protocol. Participants on active treatment showed significantly greater improvements in tender point count and tender point pain, quality of life, global health and a trend toward less depression compared with those on placebo.

CONCLUSIONS:

This study replicates and extends a previous 1-month placebo-controlled crossover study in fibromyalgia that pre-screened for only one homeopathic remedy. Using a broad selection of remedies and the flexible LM dose (1/50,000 dilution factor) series, the present study demonstrated that individualized homeopathy is significantly better than placebo in lessening tender point pain and improving the quality of life and global health of persons with fibromyalgia.


Bell I.R., Lewis D.A. 2nd, Brooks A.J., Schwartz G.E., Lewis S.E., Walsh B.T., Baldwin, C.M., "Improved clinical status in fibromyalgia patients treated with individualized homeopathic remedies versus placebo", 2004; Rheumatology, 43(5): 577-582.

http://www.ncbi.nlm.nih.gov/pubmed/14734789
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Re: RICERCA SCIENTIFICA OMEOPATICA

Messaggiodi Dr.Ascani il mer giu 01, 2016 1:37 pm

Homeopathic medical practice: long-term results of a cohort study with 3981 patients.

CONCLUSION:

Disease severity and quality of life demonstrated marked and sustained improvements following homeopathic treatment period. Our findings indicate that homeopathic medical therapy may play a beneficial role in the long-term care of patients with chronic diseases

Witt C.M., Lüdtke R., Baur R., Willich S.N., "Homeopathic medical practice: long-term results of a cohort study with 3981 patients", BMC Public Health. 2005; 5:115.

http://www.ncbi.nlm.nih.gov/pubmed/16266440
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Re: RICERCA SCIENTIFICA OMEOPATICA

Messaggiodi Dr.Ascani il mer giu 01, 2016 1:39 pm

Effects of homeopathic preparations on human prostate cancer growth in cellular and animal models.

Abstract

The use of dietary supplements for various ailments enjoys unprecedented popularity. As part of this trend, Sabal serrulata (saw palmetto) constitutes the complementary treatment of choice with regard to prostate health. In homeopathy, Sabal serrulata is commonly prescribed for prostate problems ranging from benign prostatic hyperplasia to prostate cancer. The authors' work assessed the antiproliferative effects of homeopathic preparations of Sabal serrulata, Thuja occidentalis, and Conium maculatum, in vivo, on nude mouse xenografts, and in vitro, on PC-3 and DU-145 human prostate cancer as well as MDA-MB-231 human breast cancer cell lines. Treatment with Sabal serrulata in vitro resulted in a 33% decrease of PC-3 cell proliferation at 72 hours and a 23% reduction of DU-145 cell proliferation at 24 hours (P<.01). The difference in reduction is likely due to the specific doubling time of each cell line. No effect was observed on MDA-MB-231 human breast cancer cells. Thuja occidentalis and Conium maculatum did not have any effect on human prostate cancer cell proliferation. In vivo, prostate tumor xenograft size was significantly reduced in Sabal serrulata-treated mice compared to untreated controls (P=.012). No effect was observed on breast tumor growth. Our study clearly demonstrates a biologic response to homeopathic treatment as manifested by cell proliferation and tumor growth. This biologic effect was (i)significantly stronger to Sabal serrulata than to controls and (ii)specific to human prostate cancer. Sabal serrulata should thus be further investigated as a specific homeopathic remedy for prostate pathology.


MacLaughlin B.W., Gutsmuths B., Pretner E., Jonas W.B., Ives J., Kulawardane D.V., Amri H., "Effects of homeopathic preparations on human prostate cancer growth in cellular and animal models", Integrative Cancer Therapies, 2006; 5(4): 362-372.

http://www.ncbi.nlm.nih.gov/pubmed/17101766
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Re: RICERCA SCIENTIFICA OMEOPATICA

Messaggiodi Dr.Ascani il mer giu 01, 2016 1:41 pm

Effect of homeopathic medicines on transplanted tumors in mice.

Abstract

Ultra low doses used in homeopathic medicines are reported to have healing potential for various diseases but their action remains controversial. In this study we have investigated the antitumour and antimetastatic activity of selected homeopathic medicines against transplanted tumours in mice. It was found that Ruta graveolens 200c and Hydrastis canadensis 200c significantly increased the lifespan of Ehrlich Ascites Carcinoma and Dalton's Lymphoma Ascites induced tumour-bearing animals by 49.7%, and 69.4% respectively. Moreover there was 95.6% and 95.8% reduction of solid tumour volume in Ruta 200c and Hydrastis 200c treated animals on the 31st day after tumour inoculation. Hydrastis 1M given orally significantly inhibited the growth of developed solid tumours produced by DLA cells and increased the lifespan of tumour bearing animals. Some 9 out of 15 animals with developed tumors were completely tumour free after treatment with Hydrastis 1M. Significant anti-metastatic activity was also found in B16F-10 melanoma-bearing animals treated with Thuja1M, Hydrastis 1M and Lycopodium1M. This was evident from the inhibition of lung tumour nodule formation, morphological and histopathological analysis of lung and decreased levels of gamma-GT in serum, a cellular marker of proliferation. These findings support that homeopathic preparations of Ruta and Hydrastis have significant antitumour activity. The mechanism of action of these medicines is not known at present.


Sunilia Es, Kuttan G., KC P., Kuttan R., "Effect of homeopathic medicines on transplanted tumors in mice", Asian pacific journal of cancer prevention, 2007; 8(3): 390-394.

http://www.ncbi.nlm.nih.gov/pubmed/18159975
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Messaggiodi Dr.Ascani il mer giu 01, 2016 1:49 pm

The 'Memory of Water': an almost deciphered enigma. Dissipative structures in extremely dilute aqueous solutions.

Abstract

In the last decade, we have investigated from the physicochemical point of view, whether water prepared by the procedures of homeopathic medicine (leading inexorably to systems without any molecule different from the solvent) results in water different from the initial water? The answer, unexpectedly, but strongly supported by many experimental results is positive. We used well-established physicochemical techniques: flux calorimetry, conductometry, pHmetry and galvanic cell electrodes potential. Unexpectedly the physicochemical parameters evolve in time. The water solvent exhibits large changes in measurable physicochemical properties as a function of its history, the solute previously dissolved, and time. In particular we found evidence of two new phenomena, both totally unpredicted,in homeopathic dilutions: the presence of a maximum in the measured physicochemical parameters vs sample age, and their dependence on the volume in which the dilution is stored. These new experimental results strongly suggest the presence of an extended and 'ordered' dynamics involving liquid water molecules

Elia V., Napoli E., Germano R., "The 'Memory of Water': an almost deciphered enigma. Dissipative structures in extremely dilute aqueous solutions", Homeopathy, 2007; 96(3) :163-699.

http://www.ncbi.nlm.nih.gov/pubmed/17678812
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Messaggiodi Dr.Ascani il mer giu 01, 2016 1:53 pm

CONFRONTO TRA TRATTAMENTO OMEOPATICO E TRATTAMENTO CONVENZIONALE DEI BAMBINI CON ECZEMA: UNO STUDIO DI COORTE COMPARATIVO

Conclusioni
"Questo studio osservazionale è la prima indagine prospettica a lungo termine per confrontare il trattamento omeopatico e convenzionale di eczema nei bambini. Durante un periodo di 12 mesi, entrambi i gruppi di terapia sono migliorati in modo simile per quanto riguarda la percezione dei sintomi dell'eczema (valutati dai pazienti o dai genitori) e la qualità della vita legata alla malattia."


Homoeopathic versus conventional treatment of children with eczema: a comparative cohort study.

Abstract

OBJECTIVES:

To assess, over a period of 12 months, whether homoeopathic treatment could influence eczema signs/symptoms and quality of life (QoL) compared with conventional treatment.

DESIGN:

Prospective multi-centre cohort study.

SETTING:

Children with eczema aged 1-16 years were recruited from primary care practices.

INTERVENTIONS:

Conventional versus homoeopathic treatment.

OUTCOME MEASURES:

Patients (or parents) assessed eczema symptoms by numerical rating scales as well as disease-specific Atopie Lebensqualitaets-Fragebogen (ALF) and general quality of life (KINDL, KITA) at 0, 6 and 12 months.

RESULTS:

A total of 118 children were included: 54 from homoeopathic (mean age+/-S.D. was 5.1+/-3.3 years; 56% boys) and 64 from conventional practices (6.2+/-3.8 years; 61% boys). Eczema symptoms (assessed by patients or their parents) improved from 0 to 12 months for both treatment options, but did not differ between the two groups: 3.5-2.5 versus 3.4-2.1; p=0.447 (adjusted). Disease-related quality of life improved in both groups similarly. In the subgroup of children aged 8-16 years the general quality of life showed a better trend for conventional treatment compared with homoeopathic treatment (p=0.030).

CONCLUSIONS:

This observational study is the first long-term prospective investigation to compare homoeopathic and conventional treatment of eczema in children. Over a period of 12 months, both therapy groups improved similarly regarding perception of eczema symptoms (assessed by patients or parents) and disease-related quality of life.

Keil T., Witt C.M., Roll S., Vance W., Weber K., Wegscheider K., Willich S.N., "Homoeopathic versus conventional treatment of children with eczema: a comparative cohort study", Complementary Therapies in Medicine, 2008; 16(1): 15-21.

http://www.ncbi.nlm.nih.gov/pubmed/18346624
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Re: RICERCA SCIENTIFICA OMEOPATICA

Messaggiodi Dr.Ascani il mer giu 01, 2016 1:56 pm

Homeopathic treatment of patients with chronic low back pain: A prospective observational study with 2 years' follow-up.

Abstract

OBJECTIVES:

To evaluate the details and effects of an individualized homeopathic treatment in patients with chronic low back pain in usual care.

METHODS:

Prospective multicenter observational study. Consecutive patients beginning homeopathic treatment in primary care practices were evaluated over 2 years by using standardized questionnaires. Diagnoses (ICD-9) and symptoms with severity, health-related quality of life (QoL), medical history, consultations, homeopathic and conventional treatments, and other health service use were recorded.

RESULTS:

One hundred twenty-nine adults (64.3% women, mean age 43.6 +/- 12.7 y) were treated by 48 physicians. The patients mainly had chronic low back pain (average duration 9.6 +/- 9.0 y) and other chronic diseases. Nearly all the patients (91.3%) had been pretreated. The initial case-taking took 113 +/- 36, and the case analysis took 31 +/- 38 minutes. The 7.4 +/- 8.1 subsequent consultations (duration: 23.7 +/- 15.2 min) cumulated to 204.5 +/- 184.6 minutes. The patients received an average of 6.8 +/- 6.3 homeopathic prescriptions. The severity of the diagnoses and complaints showed marked and sustained improvements with large effect sizes (Cohen's d from 1.67 to 2.55) and QoL improved accordingly (SF-36 physical component scale d = 0.33; mental component scale d = 0.54). The use of conventional treatment and health services decreased markedly: the number of patients using low back pain-related drugs was half of the baseline.

DISCUSSION:

Classic homeopathic treatment represents an effective treatment for low back pain and other diagnoses. It improves health-related QoL and reduces the use of other healthcare services.

Witt C.M., Lüdtke R., Baur R., Willich S.N., "Homeopathic treatment of patients with chronic low back pain: A prospective observational study with 2 years' follow-up", The Clinical Journal of Pain, 2009; 25(4): 334-339.

http://www.ncbi.nlm.nih.gov/pubmed/19590483
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Messaggiodi Dr.Ascani il mer giu 01, 2016 1:57 pm

EFFETTI CITOTOSSICI DEI RIMEDI ULTRA-DILUITI SULLE CELLULE TUMORALI DEL SENO
"I risultati dimostrano l'attività biologica di questi prodotti naturali quando vengono dati a dosi ultra-diluite. Ulteriori approfondimenti con ulteriori linee cellulari e modelli animali sono giustificati per esplorare l'applicabilità clinica di questi agenti."

Cytotoxic effects of ultra-diluted remedies on breast cancer cells.

Abstract

The use of ultra-diluted natural products in the management of disease and treatment of cancer has generated a lot of interest and controversy. We conducted an in vitro study to determine if products prescribed by a clinic in India have any effect on breast cancer cell lines. We studied four ultra-diluted remedies (Carcinosin, Phytolacca, Conium and Thuja) against two human breast adenocarcinoma cell lines (MCF-7 and MDA-MB-231) and a cell line derived from immortalized normal human mammary epithelial cells (HMLE). The remedies exerted preferential cytotoxic effects against the two breast cancer cell lines, causing cell cycle delay/arrest and apoptosis. These effects were accompanied by altered expression of the cell cycle regulatory proteins, including downregulation of phosphorylated Rb and upregulation of the CDK inhibitor p27, which were likely responsible for the cell cycle delay/arrest as well as induction of the apoptotic cascade that manifested in the activation of caspase 7 and cleavage of PARP in the treated cells. The findings demonstrate biological activity of these natural products when presented at ultra-diluted doses. Further in-depth studies with additional cell lines and animal models are warranted to explore the clinical applicability of these agents.


Frenkel M., Mishra B.M., Sen S., Yang P., Pawlus A., Vence L., Leblanc A., Cohen L., Banerji P., Banerji P., "Cytotoxic effects of ultra-diluted remedies on breast cancer cells", International Journal of Oncology, 2010; 36(2): 395-403.

http://www.ncbi.nlm.nih.gov/pubmed/20043074
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Messaggiodi Dr.Ascani il mer giu 01, 2016 1:59 pm

Dose-effect study of Gelsemium sempervirens in high dilutions on anxiety-related responses in mice

Abstract

INTRODUCTION:

This study was designed to investigate the putative anxiolytic-like activity of ultra-low doses of Gelsemium sempervirens (G. sempervirens), produced according to the homeopathic pharmacopeia.

METHODS:

Five different centesimal (C) dilutions of G. sempervirens (4C, 5C, 7C, 9C and 30C), the drug buspirone (5 mg/kg) and solvent vehicle were delivered intraperitoneally to groups of ICR-CD1 mice over a period of 9 days. The behavioral effects were assessed in the open-field (OF) and light-dark (LD) tests in blind and randomized fashion.

RESULTS:

Most G. sempervirens dilutions did not affect the total distance traveled in the OF (only the 5C had an almost significant stimulatory effect on this parameter), indicating that the medicine caused no sedation effects or unspecific changes in locomotor activity. In the same test, buspirone induced a slight but statistically significant decrease in locomotion. G. sempervirens showed little stimulatory activity on the time spent and distance traveled in the central zone of the OF, but this effect was not statistically significant. In the LD test, G. sempervirens increased the % time spent in the light compartment, an indicator of anxiolytic-like activity, with a statistically significant effect using the 5C, 9C and 30C dilutions. These effects were comparable to those of buspirone. The number of transitions between the compartments of the LD test markedly increased with G. sempervirens 5C, 9C and 30C dilutions.

CONCLUSION:

The overall pattern of results provides evidence that G. sempervirens acts on the emotional reactivity of mice, and that its anxiolytic-like effects are apparent, with a non-linear relationship, even at high dilutions.


Magnani P., Conforti A., Zanolin E., Marzotto M., Bellavite P., "Dose-effect study of Gelsemium sempervirens in high dilutions on anxiety-related responses in mice", Psychopharmacology (Berl), 2010; 210: 533-545.

http://www.ncbi.nlm.nih.gov/pubmed/20401745
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Messaggiodi Dr.Ascani il mer giu 01, 2016 2:02 pm

Homeopathic Doses of Gelsemium sempervirens Improve the Behavior of Mice in Response to Novel Environments.

Abstract

Gelsemium sempervirens is used in homeopathy for treating patients with anxiety related symptoms, however there have been few experimental studies evaluating its pharmacological activity. We have investigated the effects of homeopathic doses of G. sempervirens on mice, using validated behavioral models. Centesimal (CH) dilutions/dynamizations of G. sempervirens, the reference drug diazepam (1 mg/kg body weight) or a placebo (solvent vehicle) were intraperitoneally delivered to groups of mice of CD1 strain during 8 days, then the effects were assessed by the Light-Dark (LD) choice test and by the Open-Field (OF) exploration test, in a fully blind manner. In the LD test, the mean time spent in the illuminated area by control and placebo-treated animals was 15.98%, for mice treated with diazepam it increased to 19.91% (P = .047), while with G. sempervirens 5 CH it was 18.11% (P = .341, non-significant). The number of transitions between the two compartments increased with diazepam from 6.19 to 9.64 (P < .001) but not with G. Sempervirens. In the OF test, G. sempervirens 5 CH significantly increased the time spent and the distance traveled in the central zone (P = .009 and P = .003, resp.), while diazepam had no effect on these OF test parameters. In a subsequent series of experiments, G. sempervirens 7 and 30 CH also significantly improved the behavioral responses of mice in the OF test (P < .01 for all tested variables). Neither dilutions of G. sempervirens affected the total distance traveled, indicating that the behavioral effect was not due to unspecific changes in locomotor activity. In conclusion, homeopathic doses of G. sempervirens influence the emotional responses of mice to novel environments, suggesting an improvement in exploratory behavior and a diminution of thigmotaxis or neophobia.

Bellavite P., Magnani P., Zanolin E., Conforti A., "Homeopathic Doses of Gelsemium sempervirens Improve the Behavior of Mice in Response to Novel Environments", Evidence-based complementary and alternative medicine, 2011; 2011: 362517.

http://www.ncbi.nlm.nih.gov/pubmed/19752165
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