RICERCA SCIENTIFICA OMEOPATICA

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Re: RICERCA SCIENTIFICA OMEOPATICA

Messaggiodi Dr.Ascani il mer giu 01, 2016 2:03 pm

Omeopatia classica nel trattamento dei pazienti affetti da cancro - uno studio osservazionale prospettico di due coorti indipendenti.

Conclusioni.
Nel nostro studio prospettico, abbiamo osservato un miglioramento della qualità della vita e una diminuizione dei sintomi legati alla stanchezza nei pazienti affetti da tumore in trattamento complementare omeopatico.

Classical homeopathy in the treatment of cancer patients--a prospective observational study of two independent cohorts.

Abstract

BACKGROUND:

Many cancer patients seek homeopathy as a complementary therapy. It has rarely been studied systematically, whether homeopathic care is of benefit for cancer patients.

METHODS:

We conducted a prospective observational study with cancer patients in two differently treated cohorts: one cohort with patients under complementary homeopathic treatment (HG; n = 259), and one cohort with conventionally treated cancer patients (CG; n = 380). For a direct comparison, matched pairs with patients of the same tumour entity and comparable prognosis were to be formed. Main outcome parameter: change of quality of life (FACT-G, FACIT-Sp) after 3 months. Secondary outcome parameters: change of quality of life (FACT-G, FACIT-Sp) after a year, as well as impairment by fatigue (MFI) and by anxiety and depression (HADS).

RESULTS:

HG: FACT-G, or FACIT-Sp, respectively improved statistically significantly in the first three months, from 75.6 (SD 14.6) to 81.1 (SD 16.9), or from 32.1 (SD 8.2) to 34.9 (SD 8.32), respectively. After 12 months, a further increase to 84.1 (SD 15.5) or 35.2 (SD 8.6) was found. Fatigue (MFI) decreased; anxiety and depression (HADS) did not change. CG: FACT-G remained constant in the first three months: 75.3 (SD 17.3) at t0, and 76.6 (SD 16.6) at t1. After 12 months, there was a slight increase to 78.9 (SD 18.1). FACIT-Sp scores improved significantly from t0 (31.0 - SD 8.9) to t1 (32.1 - SD 8.9) and declined again after a year (31.6 - SD 9.4). For fatigue, anxiety, and depression, no relevant changes were found. 120 patients of HG and 206 patients of CG met our criteria for matched-pairs selection. Due to large differences between the two patient populations, however, only 11 matched pairs could be formed. This is not sufficient for a comparative study.

CONCLUSION:

In our prospective study, we observed an improvement of quality of life as well as a tendency of fatigue symptoms to decrease in cancer patients under complementary homeopathic treatment. It would take considerably larger samples to find matched pairs suitable for comparison in order to establish a definite causal relation between these effects and homeopathic treatment.


Rostock M., Naumann J., Guethlin C., Guenther L., Bartsch H.H., Walach H., "Classical homeopathy in the treatment of cancer patients - a prospective observational study of two independent cohorts", BMC Cancer, 2011; 11:19.

http://www.ncbi.nlm.nih.gov/pubmed/21241504
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Re: RICERCA SCIENTIFICA OMEOPATICA

Messaggiodi Dr.Ascani il mer giu 01, 2016 2:15 pm

Induction of apoptosis of tumor cells by some potentiated homeopathic drugs: implications on mechanism of action.

Abstract

BACKGROUND:

Homoeopathic medicines treat diseases, including cancer, using ultradiluted preparations. Earlier studies indicated that homoeopathic medicines are cytotoxic to tumor cells and reduced animal tumors. However, the mechanism of homoeopathic medicines at the cellular level is not known.

METHODS:

The following drugs were used in the study: Ruta 200C, Carcinosinum 200C, Hydrastis 200C, Thuja 200C, and Thuja 1M. These drugs were tested for their ability to induce apoptosis as seen by morphology, DNA laddering, expression of genes related to apoptosis, and TUNEL assay. Similarly, the effect of homoeopathic medicines on apoptosis was measured by microarray analysis. Activity of Ruta 200C was compared with that of the mother tincture.

RESULTS:

Ruta 200C produced morphological changes in the Dalton's lymphoma ascites tumor cells and induced DNA laddering. Carcinosinum 200C increased apoptotic gene p53 and Ruta 200C decreased antiapoptotic gene Bcl2. Administration of potentiated homoeopathic drugs to tumor-bearing mice induced TUNEL-positive cells in the tumor, showing increased apoptosis of tumor cells. Microarray analysis of cells treated with homoeopathic drugs indicated that many enzymes related to apoptosis were increased by homoeopathic drugs.

CONCLUSION:

These data indicate that apoptosis is one of the mechanisms of tumor reduction of homeopathic drugs. A comparison of potentiated drugs with their mother tincture indicated that the potentiated drugs have biological activity similar to that of their mother tincture in spite of ultradilution.

Preethi K., Ellanghiyil S., Kuttan G., Kuttan R., "Induction of apoptosis of tumor cells by some potentiated homeopathic drugs: implications on mechanism of action", Integrative Cancer Therapies, 2012; 11(2): 172-182.

http://www.ncbi.nlm.nih.gov/pubmed/21771822
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Re: RICERCA SCIENTIFICA OMEOPATICA

Messaggiodi Dr.Ascani il mer giu 01, 2016 2:21 pm

Homeopathic Thuja 30C ameliorates benzo(a)pyrene-induced DNA damage, stress and viability of perfused lung cells of mice in vitro.

Abstract

OBJECTIVE:

To examine if the ultra-highly diluted homeopathic remedy Thuja 30C can ameliorate benzo(a)pyrene (BaP)-induced DNA damage, stress and viability of perfused lung cells of Swiss albino mice in vitro.

METHODS:

Perfused normal lung cells from mice were cultured in 5% Roswell Park Memorial Institute medium and exposed to BaP, a potent carcinogen, at the half maximal inhibitory concentration dose (2.2 μmol/L) for 24 h. Thereafter, the intoxicated cells were either treated with Thuja 30C (used against tumor or cancer) or its vehicle media, succussed alcohol 30C. Relevant parameters of study involving reactive oxygen species (ROS) accumulation, total glutathione (GSH) content, and generations of heat shock protein (hsp)-90 were measured; the cell viability and other test parameters were measured after treatment with either Thuja 30C or its vehicle media. Circular dichroism spectroscopy was performed to examine if Thuja 30C directly interacted with calf thymus DNA as target. For ascertaining if DNA damaged by BaP could be partially repaired and restituted by the remedy, 4',6-diamidino-2-phenylindole staining was performed.

RESULTS:

Thuja 30C increased cell viability of BaP-intoxicated cells significantly, as compared to drug-untreated or drug-vehicle control. A minimal dose of Thuja 30C significantly inhibited BaP-induced stress level, by down-regulating ROS and hsp-90, and increasing GSH content. Thuja 30C itself had no DNA-damaging effect, and no direct drug-DNA interaction. However, it showed quite striking ability to repair DNA damage caused by BaP.

CONCLUSION:

Thuja 30C ameliorates BaP-induced toxicity, stress and DNA damage in perfused lung cells of mice and it apparently has no effect on normal lung cells.

Mukherjee A., Boujedaini N., Khuda-Bukhsh A.R., "Homeopathic Thuja 30C ameliorates benzo(a)pyrene-induced DNA damage, stress and viability of perfused lung cells of mice in vitro", Journal of Integrative Medicine, 2013; 11(6): 397-404.

http://www.ncbi.nlm.nih.gov/pubmed/24299603
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Re: RICERCA SCIENTIFICA OMEOPATICA

Messaggiodi Dr.Ascani il mer giu 01, 2016 2:24 pm

Anti-proliferative effects of homeopathic medicines on human kidney, colon and breast cancer cells.

Abstract

OBJECTIVE:

Homeopathy is controversial, due to the claims made for very high dilutions. Although several theories are proposed to understand the mechanisms of action, none are scientifically verified. This study aimed to investigate the efficacy of the selected homeopathic medicines in specific in vitro cancer models.

METHODS:

We assessed the cytotoxic activity of selected homeopathic medicines in mother tincture (MT), and ultramolecular dilution (30C, 200C, 1M and 10M) against cell lines deriving from tumors of particular organs, Sarsaparilla (Sars) on ACHN cells (human renal adenocarcinoma), Ruta graveolens (Ruta) on COLO-205 (human colorectal carcinoma), and Phytolacca decandra (Phyto) on MCF-7 (human breast carcinoma). Sars was also tested against Madin-Darby canine kidney (MDCK) cells (a non-malignant cell line). Cytotoxicity was measured using the 3-(4, 5-dimethylthiazolyl-2)-2, 5-diphenyltetrazolium bromide (MTT) method, anti-proliferative activity by trypan blue exclusion assay, apoptosis determined by dual staining the cells with ethidium bromide (EB) and acridine orange (AO) dyes.

RESULTS:

MTs and ultra-diluted preparations of the three homeopathic medicines had highly significant effects in the respective cancer cell lines, producing cytotoxicity and a decrease in cell proliferation. The effects were greatest with the MTs, but in all cases and persisted, although to a lesser degree in the ultra-diluted molecular preparations. Sars showed no effect on MDCK cells. In the homeopathic medicine treated cultures, hallmarks of apoptosis were evident including, cell shrinkage, chromatin condensation and DNA fragmentation.

CONCLUSION:

This study provides preliminary laboratory evidence indicating the ability of homeopathic medicines as anticancer agents. Further studies of the action of these homeopathic remedies are warranted.

Arora S., Aggarwal A., Singla P., Jyoti S., Tandon S., "Anti-proliferative effects of homeopathic medicines on human kidney, colon and breast cancer cells", Homeopathy, 2013; 102(4): 274-282.

http://www.ncbi.nlm.nih.gov/pubmed/24050774
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Re: RICERCA SCIENTIFICA OMEOPATICA

Messaggiodi Dr.Ascani il mer giu 01, 2016 2:25 pm

Calcarea carbonica induces apoptosis in cancer cells in p53-dependent manner via an immuno-modulatory circuit

Conclusion

In summary, our work for the first time indicated an apoptosis-enhancing capability of calcarea carbonica in cancer cells by strengthening the immune system as well as the cross-talk of various pro- and anti-apoptotic factors. Even though further investigations and clinical trials are needed there is an indication that the unique properties of calcarea carbonica can be exploited for regression of tumor burden by rejuvenating host’s depressed immune system without inducing systemic toxicity.

Saha S., Hossain D.M., Mukherjee S., Mohanty S., Mazumdar M., Mukherjee S., Ghosh U.K., Nayek C., Raveendar C., Khurana A., Chakrabarty R., Sa G., Das T., "Calcarea carbonica induces apoptosis in cancer cells in p53-dependent manner via an immuno-modulatory circuit", BMC Complementary and Alternative Medicine, 2013; 13: 230.

http://bmccomplementalternmed.biomedcen ... 882-13-230
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Re: RICERCA SCIENTIFICA OMEOPATICA

Messaggiodi Dr.Ascani il mer giu 01, 2016 2:28 pm

Integrative nanomedicine: treating cancer with nanoscale natural products.

Abstractin English, Chinese, Spanish

Finding safer and more effective treatments for specific cancers remains a significant challenge for integrative clinicians and researchers worldwide. One emerging strategy is the use of nanostructured forms of drugs, vaccines, traditional animal venoms, herbs, and nutraceutical agents in cancer treatment. The recent discovery of nanoparticles in traditional homeopathic medicines adds another point of convergence between modern nanomedicine and alternative interventional strategies. A way in which homeopathic remedies could initiate anticancer effects includes cell-to-cell signaling actions of both exogenous and endogenous (exosome) nanoparticles. The result can be a cascade of modulatory biological events with antiproliferative and pro-apoptotic effects. The Banerji Protocols reflect a multigenerational clinical system developed by homeopathic physicians in India who have treated thousands of patients with cancer. A number of homeopathic remedy sources from the Banerji Protocols (eg, Calcarea phosphorica; Carcinosin-tumor-derived breast cancer tissue prepared homeopathically) overlap those already under study in nonhomeopathic nanoparticle and nanovesicle tumor exosome cancer vaccine research. Past research on antineoplastic effects of nano forms of botanical extracts such as Phytolacca, Gelsemium, Hydrastis, Thuja, and Ruta as well as on homeopathic remedy potencies made from the same types of source materials suggests other important overlaps. The replicated finding of silica, silicon, and nano-silica release from agitation of liquids in glassware adds a proven nonspecific activator and amplifier of immunological effects. Taken together, the nanoparticulate research data and the Banerji Protocols for homeopathic remedies in cancer suggest a way forward for generating advances in cancer treatment with natural product-derived nanomedicines.

Bell I.R., Sarter B., Koithan M., Banerji P., Banerji P., Jain S., Ives J., "Integrative nanomedicine: treating cancer with nanoscale natural products", Global advances in health and medicine, 2014; 3(1): 36-53.

http://www.ncbi.nlm.nih.gov/pubmed/24753994
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Re: RICERCA SCIENTIFICA OMEOPATICA

Messaggiodi Dr.Ascani il mer giu 01, 2016 2:30 pm

Sulphur alters NFκB-p300 cross-talk in favour of p53-p300 to induce apoptosis in non-small cell lung carcinoma.

Abstract

Adverse side effects of chemotherapy during cancer treatment have shifted considerable focus towards therapies that are not only targeted but are also devoid of toxic side effects. We evaluated the antitumorigenic activity of sulphur, and delineated the molecular mechanisms underlying sulphur-induced apoptosis in non-small cell lung carcinoma (NSCLC) cells. A search for the underlying mechanism revealed that the choice between the two cellular processes, NFκBp65-mediated survival and p53-mediated apoptosis, was decided by the competition for a limited pool of transcriptional coactivator protein p300 in NSCLC cells. In contrast, sulphur inhibited otherwise upregulated survival signaling in NSCLC cells by perturbing the nuclear translocation of p65NFκB, its association with p300 histone acetylase, and subsequent transcription of Bcl-2. Under such anti-survival condition, induction of p53-p300 cross-talk enhanced the transcriptional activity of p53 and intrinsic mitochondrial death cascade. Overall, the findings of this preclinical study clearly delineated the molecular mechanism underlying the apoptogenic effect of the non-toxic homeopathic remedy, sulphur, in NSCLC cells.


Saha S., Bhattacharjee P., Guha D., Kajal K., Khan P., Chakraborty S., Mukherjee S., Paul S., Manchanda R., Khurana A., Nayak D., Chakrabarty R., Sa G., Das T., "Sulphur alters NFκB-p300 cross-talk in favour of p53-p300 to induce apoptosis in non-small cell lung carcinoma", International Journal of Oncology, 2015; 47(2): 573-582.

http://www.ncbi.nlm.nih.gov/pubmed/26095308
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Re: RICERCA SCIENTIFICA OMEOPATICA

Messaggiodi Dr.Ascani il ven giu 17, 2016 3:27 pm

RICERCA
Acqua e omeopatia, l'informazione corre sul filo

di Carlo Di Stanislao

Questo stesso gruppo indiano di studio aveva già dimostrato in una serie di esperimenti precedenti che il trattamento di una pianta o animale con una sostanza diluita e dinamizzata può influenzare altre piante o animali connessi ai primi mediante acqua capillare trasferita per mezzo di fili di cotone. In un nuovo studio pubblicato sull'International Journal of High Diluition Research due provette, ciascuna contenente 1 ml di soluzione di amido 1% e 1 ml di alfa-amilasi, sono state collegate mediante fili di cotone racchiusi in un tubo di polietilene. Uno dei tubi conteneva anche Mercurius corrosivus 30CH, mentre l'altra soluzione veniva riempita di etanolo come controllo. Dopo 15 minuti, l'attività enzimatica è stata bloccata mediante DDN-polimerasi e ed è stato stimato il prodotto di degradazione di amido e maltosio. In questo studio si è anche usato un terzo tubo, contenente i materiali testati tranne Mercurius e soluzione di controllo. In questo esperimento la quantità di maltosio era simile in entrambi i tubi collegati, ma era significativamente inferiore nel terzo tubo scollegato. Si è quindi proceduto ad un secondo esperimento in cui due tubi, uno contenente 1200 ppm e l'altra di 200 ppm di maltosio, sono stati in contatto con le medesime modalità per oltre 15 minuti. In questo caso la concentrazione maltosio in entrambi i tubi è rimasta invariata, dimostrando che le informazioni di Mercurius corrosivus 30CH con blocco della alfa-amilasi siano state effettivamente trasferite attraverso l'acqua capillare tra i due tubi in un mezzo privo di elementi cellulari. In effetti, per le modalità con cui sono stati condotti i due esperimenti questo effetto non può imputarsi al trasferimento fisico di un solvente o di soluti, mentre si può ragionevolmente affermare che l'acqua sia portatrice di informazioni specifiche in soluzioni diluite e dinamizzate oltre il numero di Avogadro.

Int J High Dil Res, 2015, 14, (1), 4
http://www.siomi.it/transfer-of-the-eff ... ary-water/

Fonte:
Omeopatia33, 17 giugno 2016 - Anno 11, Numero 9
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Re: RICERCA SCIENTIFICA OMEOPATICA

Messaggiodi Dr.Ascani il lun giu 20, 2016 9:47 pm

L'omeopatia, una bella automobile che in veterinaria va da sola

di Massimo Saruggia

Agli uomini, spesso con la barba, che usano parole difficili per dire astruserie sulla implausibilità dell'omeopatia, bisognebbe far leggere un articolo di un gruppo di ricerca italiano, guidato da Sergio Canello della scuola di Omeopatia di Verona, pubblicato da Homeopathy. L'articolo è molto semplice, molto saggio e quindi - per loro - impossibile da leggere. Ma si sa: è più facile per un cammello eccetera, eccetera...
I nostri autori partono da 96 polli, li dividono in quattro gruppi e random li nutrono per due anni con regimi alimentari diversi che hanno tutti in comune l'alimentazione normale dei polli di allevamento, ma che differiscono tra di loro per un quid fondamentale che li differenzia (uno con Symphytum 9CH, uno con un complesso che veicola le tre calcaree alla 4CH, uno con la sola Calcarea carbonica 30CH e l'ultimo con un placebo). Il razionale dello studio poggia su una solida base esperienziale: la mineralizzazione dei polli in batteria è molto bassa, creando in questo modo una debolezza strutturale del loro apparato di sostegno. L'obiettivo era verificare la capacità degli elementi omeopatici introdotti nella normale dieta di aumentare la concentrazione di calcio nel tessuto osseo sternale attraverso una misura obiettiva come la TAC, alla quale tutti i polli sono stati sottoposti dopo due anni.
I risultati sono notevoli e parlano di miglioramenti percentuali di mineralizzazione a due cifre nei confronti del placebo
: 30%, 36% e 63% rispettivamente per Symphytum, complesso di tricalcaree e Calcarea Carbonica da sola. Per quest'ultima una significatività davvero gratificante (p<0,001). La conclusione degli autori è ovviamente che, per migliorarne lo stato di salute, queste preparazioni omeopatiche dovrebbero entrare regolarmente nel regime alimentare di questi animali. E che aggiungiamo noi, per chi si occupa criticamente o benevolmente di medicina integrata, la lettura di questi lavori dovrebbe forzatamente entrare nel proprio ricettario culturale del cotto e del crudo, del dolce e del salato.

Homeopathy, 2016, 105, (1), 92

Fonte:
Omeopatia33
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Re: RICERCA SCIENTIFICA OMEOPATICA

Messaggiodi Dr.Ascani il ven lug 08, 2016 10:02 am

CLINICA PRATICA
Omeopatia nella prevenzione delle infezioni respiratorie recidivanti

di Silvia Cocci Grifoni

Uno studio osservazionale retrospettivo e controllato, pubblicato su Multidisciplinary Respiratory Medicine da Gianfranco Maria Beghi e Antonio Maria Morselli-Labate esamina l'andamento delle recidive di infezioni del tratto respiratorio (RTI) in un gruppo di pazienti sottoposti a terapia omeopatica versus un gruppo di controllo non trattato, con l'obiettivo di valutare il ruolo dell'omeopatia nella prevenzione delle RTI. Lo studio è stato svolto dal 2002 al 2011 ed ha arruolato in successione 459 pazienti in totale, di cui 248 trattati con un farmaco omeopatico (Anas Barbarie, Hepatis, Cordis extractum 200K, una dose settimanale per otto mesi, per ogni anno di osservazione) mentre i rimanenti 211 pazienti non sono stati trattati (gruppo di controllo). E' stata quindi valutata la ricorrenza annua di RTI nei due gruppi in termini di otite media, otalgia, faringo-tonsillite, laringite, sinusiti ed infezioni streptococciche.
L'analisi dei risultati ha mostrato che, sebbene il gruppo dei pazienti trattati manifestasse prima dello studio un numero maggiore di RTI annui, nel follow-up il numero di RTI era significativamente più basso rispetto al gruppo di controllo. L'efficacia del trattamento omeopatico inoltre non era statisticamente correlabile a sesso, età, tabagismo o eventuali patologie respiratorie associate se confrontata con il gruppo di controllo. Appare quindi ragionevole concludere che il trattamento omeopatico possiede un effetto preventivo nelle RTI, suggerendo un ipotetico ruolo nella gestione delle patologie nella stagione invernale in considerazione della morbilità ad esse correlate, specie nella popolazione pediatrica ed anziana.

Multidisc Resp Med, 2016, 11, (12)
http://www.siomi.it/does-homeopathic-me ... l-study-2/

Fonte:
Omeopatia33, 8 luglio 2016 - Anno 11, Numero 10
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